34 gene Personalizing treatment solution in Colorectal Cancer
 

A comprehensive next generation sequencing approach identifies colorectal cancer-related genomic alterations. Detection of NCCN recommended genes and other colorectal cancer targeted drug related, hereditary syndrome risk and immunosuppressive efficacy assessment related genes. The assay provides biomarker information to guide personalized medication, genetic risk and prognosis of patients with colorectal cancer.

 
Caner Type
Colorectal Caner
 
Biopsy Type
Tissue, FFPE, Peripheral Whole Blood
 
Results Expected
10 working days
Clinical Significance
Indication of targeted drug efficiency

The mutation rates of KRAS, NRAS, BRAF and PIK3CA are 45.5%, 3.9%, 3.1% and 3.5% respectively in colorectal cancer patients in China. KRAS, NRAS, BRAF mutations are related to poor prognosis of anti-EGFR target therapy. NCCN and other authoritative guidelines clearly require metastatic colorectal cancer patients to detect RAS/BRAF gene mutation before got targeted treatment.The CAPRI GOIM study showed that the efficacy benefit of cetuximab was limited to the high selectivity (KRAS / NRAS / BRAF / PIK3CA) "quadruple wild" population and adverse trends in the mutant population.

 

Indication of genetic risk,Guide early prevention of cancer

About 25% of patients with colorectal cancer have familial clustering, and it has been clear that about 6% of hereditary colorectal cancer is associated with a variety of genetic syndromes. The pathogenicity of genes associated with hereditary colorectal cancer was analyzed by next generation sequencing, whether the patient was hereditary colorectal cancer, providing targeted treatment regimens, and providing important information for relatives.

 

MSI results suggestion of PD-1 / PD-L1 immunotherapy prognosis

Microsatellites are short tandem repeat DNA sequences with lengths of 1-6 base pairs. These repeats are widely found in the genome. In general, the frequency of microsatellite DNA in somatic cells is 10-5-10-7. Studies have shown that patients with microsatellite instability are more likely to benefit from PD-1 immunosuppressive agents.

 

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Progression-free survival and overall survival rate compared with patients with dMMR after treatment of Pembrolizumab

Noninvasive monitoring tumor progression, revealing drug resistance mechanisms, timely adjustment of treatment programs

After several splitting proliferation, the daughter of tumor cells showing a molecular biology or genetic changes, leading tumor growth rate, invasive ability, sensitivity to the drug, prognosis and etc., differences.  As a new tumor marker in the monitoring of the dynamic development of the tumor,ctDNA has a higher sensitivity and specificity, and can be better than the protein markers and imaging predict the dynamic development of the tumor. So ctDNA can be used for cancer early diagnosis, monitoring cancer development process, prognosis and individualized medication guidance.

             

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Studies have shown that ctDNA can reflect tumor recurrence and progression more accurately than imaging and protein CEA markers.

Product Content

 

Gene list(34)

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Note:

Colorectal cancer targeted therapy related genes marked as red;

Hereditary colorectal cancer related genes marked as blue;

Other cancer targeted therapy related and driver genes marked as White.

 

Targeted drugs(20)
CFDA/FDA approved targeted drugs
  • Cetuximab
  • Panitumumab
  • Bevacizumab
  • Aflibercept
  • Regorafenib
  • Ramucirumab
Clinical test drugs
  • Sorafenib
  • Nimotuzumab
CFDA/FDA approved drugs for other cancer
  • Erlotinib
  • Gefitinib
  • Icotinib
  • Afatinib
  • Osimertinib
  • Vemurafenib
  • Dabrafenib
  • Vandetani
  • Sunitinib
  • Imatinib
  • Lapatinib
  • Pazopanib

 


       

Service Process
  • Identify test program and fill in the application form

  • Get tissue and blood samples

  • Sign informed consent

  • Shipping to cloudhealth clinical center

  • Sequencing and analysis

  • Report

Reference

 

1.    Ciardiello, et al. WCGC 2015. Abstract LBA-09

2.    Genetics of Colorectal Cancer. NCI. 2015

3.    N Engl J Med 2015;372:2509-20

4.    Evelyn Kidess-Sigal,Oncotarget, 2016, Vol. 7: 85349-85364

 


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