120 gene personalizing treatment solution is a second-generation sequencing technology used to detect and tumor development and targeted therapy-related gene products. Through the detection of cancer patients with targeted drugs, signaling pathways and tumor genetic susceptibility related genes, to guide the individual patients with cancer patients and genetic risk assessment.
Some mutations may be driver gene mutations for multiple cancers, such as ALK gene mutations that are not only driver gene for non-small cell lung cancer, but also with lymphoma, kidney cancer, neuroblastoma, and so on. This means that different cancer with the same driver gene mutation may be treated with the same drug. By detecting the target of all targeted drugs, the specific molecular typing of the tumor can be revealed to match the precise targeted drug for treatment.
PET scan showed that after using targeted drugs, liver metastases, bone metastases of the tumor tissue was significantly reduced, pleural effusion also significantly improved.
The latest study found that 2, 22 kinds of cancer are genetic related, if the immediate family members have these cancer, other brothers and sisters have the same cancer risk will increase by 33%.
By detecting BRCA gene in 1816 breast cancer patients and their 5549 first-degree female relatives, it was found that people with BRCA-induced mutations had a greater risk of developing breast cancer than those who did not carry pathogenic mutations3. Tumor hereditary related genetic detection can reveal the risk of cancer, to achieve so early detection, early diagnosis and early treatment.
After several splitting proliferation, the daughter of tumor cells showing a molecular biology or genetic changes, leading tumor growth rate, invasive ability, sensitivity to the drug, prognosis and etc., differences. As a new tumor marker in the monitoring of the dynamic development of the tumor，ctDNA has a higher sensitivity and specificity, and can be better than the protein markers and imaging predict the dynamic development of the tumor. So ctDNA can be used for cancer early diagnosis, monitoring cancer development process, prognosis and individualized medication guidance.
PPatients with high ctDNA PIK3CA mutations frequency had a shorter recurrence-free survival (P = 0.0002) and a lower overall survival (P = 0.048) than those with no mutations or low mutation frequency Multivariate analysis of OS showed that ctDNA PIK3CA mutant frequency was an independent predictor of OS.
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1. Loaiza-Bonilla A, et al. E cancer medical science. 2014. 8:479.
2. Mucci LA, et al. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. JAMA. 2016, 315(1): 68-76.
3. Yao L, et al. Breast cancer risk in Chinese women with BRCA1 or BRCA2 mutations. Breast Cancer Res Treat. 2016 Apr;156(3):441-5.
4. Breast Cancer Res Treat，2015，March.
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