Using high-throughput sequencing for accurate methylation within the scope of whole genome research.
DNA methylation at the C5 position of cytosine plays a crucial role in gene expression and chromatin remodelling, and perturbations in methylation patterns are implicated in the development of cancer, neurodegenerative diseases, and neurological disorders. Therefore, the mapping of methylated bases (the methylome) is critical to understanding gene expression and other processes subject to epigenetic regulation.
Base calling, raw data clean up and QC in pipeline.
Reference genome contrast.
Analyze methylation level, coverage, distribution of C base.
DMS, DMR and DMP analysis.
Functional enrichment analysis of DMR and DMP
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